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ea0029p122 | Adrenal medulla | ICEECE2012

A Novel SDHC mutation associated with Head-Neck Paraganglioma

Rasmussen P. , Friis-Hansen L. , Gerdes A. , Langer S. , Feldt-Rasmussen U.

Germline mutations in the succinate-dehydrogenase subunits A, B, C, and D (SDHA/B/C/D) predispose to development of the phaeochromocytoma-paraganglioma (FPGL) syndromes. SDHC and SDHD are anchoring proteins located in the inner mitochondrial membrane. The SDH complex has two major roles in energy production it is part of the tricarboxic acid cycle catalysing the oxidative dehydrogenation of succinate coupled to the reduction of ubiquinone. It is also the complex II component o...

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ea0050ja2 | Society for Endocrinology Journal Award - Journal of Molecular Endocrinology | SFEBES2017

MuRF1 mono-ubiquitinates TRα to inhibit T3 induced cardiac hypertrophy in vivo

Wadosky Kristine M , Berthiaume Jessica M , Tang Wei , Zungu Makhosi , Portman Michael A , Gerdes A Martin , Willis Monte S

Journal of Molecular Endocrinology 2016 56 273290. DOI: 10.1530/JME-15-0283...

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ea0050ja2 | Society for Endocrinology Journal Award - Journal of Molecular Endocrinology | SFEBES2017

MuRF1 mono-ubiquitinates TRα to inhibit T3 induced cardiac hypertrophy in vivo

Wadosky Kristine M , Berthiaume Jessica M , Tang Wei , Zungu Makhosi , Portman Michael A , Gerdes A Martin , Willis Monte S

Journal of Molecular Endocrinology 2016 56 273290. DOI: 10.1530/JME-15-0283...

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ea0099oc4.4 | Oral Communications 4: Diabetes, Obesity, Metabolism and Nutrition | Part I | ECE2024

Sphinganine increases GLP-1 secretion and causes weight loss in mice

Smits Mark , Drzazga Anna , Galsgaard Katrine , Lackman Jarkko , Gerdes Victor , van de Laar Arnold , Bruin Sjoerd , Rosenkilde Mette , Holst Jens J.

Recent years have demonstrated increasing focus on augmenting secretion of glucagon-like peptide (GLP)-1 from intestinal L cells, to improve the treatment and/or prevention of obesity and type 2 diabetes. However, finding strong stimuli and identifying novel compounds has proven difficult. To discover new GLP-1 secretagogues, we gave 49 individuals (76% female, BMI 28.3±4.8 kg/m2) a high-fat liquid mixed meal (250 mL Nutridrink, Nutricia®). Plasma samples,...

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Endocrine Abstracts

A Novel SDHC mutation associated with Head-Neck Paraganglioma

MuRF1 mono-ubiquitinates TRα to inhibit T3 induced cardiac hypertrophy in vivo

MuRF1 mono-ubiquitinates TRα to inhibit T3 induced cardiac hypertrophy in vivo

Sphinganine increases GLP-1 secretion and causes weight loss in mice

BiosciAbstracts